GENOME INTEGRITY

For an organism to survive and to pass on characteristics to its progeny, genome integrity must be maintained. Genomic instability can result in chromosomal abnormalities and gene mutations and is brought on by DNA damage, abnormal DNA duplication, or ad hoc cell division.

BioCapTM TERT mRNA

https://www.pharna.com/product/1600201/

Protein

Telomerase reverse transcriptase

Gene

TERT

Status

UniProtKB reviewed (Swiss-Prot)

Organism

Homo sapiens (Human)

Amino acids

1132

Protein existence

Evidence at protein level

Most organisms require the ribonucleoprotein enzyme telomerase for the replication of chromosome termini. Active in malignancy and progenitor cells. Inactive or barely functional in typical reproductive cells. The telomere-lengthening holoenzyme complex’s catalytic component functions as a reverse transcriptase, adding short sequence repetitions to chromosome ends by copying a template sequence found in the RNA component of the enzyme.

BioCapTM TERT CI (D712A) mRNA

https://www.pharna.com/product/1600201/

Protein

Telomerase reverse transcriptase

Gene

TERT

Status

UniProtKB reviewed (Swiss-Prot)

Organism

Homo sapiens (Human)

Amino acids

1132

Protein existence

Evidence at protein level

For the replication of chromosome termini in the majority of species, telomerase, a ribonucleoprotein enzyme, is necessary. Normal reproductive cells are inactive or bare-bones working. The catalytic component of the telomere-lengthening holoenzyme complex works as a reverse transcriptase, copying a template sequence found in the RNA component of the enzyme to add brief sequence repeats to chromosome ends. 

BioCapTM TERT 5′-3xFLAG mRNA

https://www.pharna.com/product/1600301/

Protein

Telomerase reverse transcriptase

Gene

TERT

Status

UniProtKB reviewed (Swiss-Prot)

Organism

Homo sapiens (Human)

Amino acids

1132

Protein existence

Evidence at protein level

The majority of species need the ribonucleoprotein enzyme telomerase to replicate chromosome ends. Normally occurring reproductive cells are inactive or absolute minimum functional. The catalytic component of the telomere-lengthening holoenzyme complex works as a reverse transcriptase, adding brief sequence repeats to chromosome ends by replicating a template sequence present in the RNA component of the enzyme. 

BioCapTM TERT 3′-3xFLAG mRNA

https://www.pharna.com/product/1600401/

Protein

Telomerase reverse transcriptase

Gene

TERT

Status

UniProtKB reviewed (Swiss-Prot)

Organism

Homo sapiens (Human)

Amino acids

1132

Protein existence

Evidence at protein level

In the majority of eukaryotes, the ribonucleoprotein enzyme telomerase is necessary for the reproduction of chromosome termini. Cancer cells and progenitor cells are active in this molecule. Normal somatic cells are inactive or very low in activity. An enzyme that acts as a reverse transcriptase to add short sequence repetitions to chromosome ends by copying a template sequence found in the RNA component of the enzyme’s catalytic component, which is essential for the elongation of telomeres. 

BioCapTM TERT 5′-3xFLAG 3′-NLS mRNA

https://www.pharna.com/product/1600501/

Protein

Telomerase reverse transcriptase

Gene

TERT

Status

UniProtKB reviewed (Swiss-Prot)

Organism

Homo sapiens (Human)

Amino acids

1132

Protein existence

Evidence at protein level

The ribonucleoprotein enzyme telomerase is required for the replication of chromosome termini in the bulk of eukaryotes. This substance stimulates the activity of progenitor cells and cancer cells. Somatic cells in the body typically have very minimal or no activity. An enzyme that replicates a template sequence located in the RNA component of the enzyme’s catalytic component, which is necessary for the elongation of telomeres, to add short sequence repetitions to chromosome ends. 

BioCapTM TERT CI (D712A) 5′-3xFLAG mRNA

https://www.pharna.com/product/1600601/

Protein

Telomerase reverse transcriptase

Gene

TERT

Status

UniProtKB reviewed (Swiss-Prot)

Organism

Homo sapiens (Human)

Amino acids

1132

Protein existence

Evidence at protein level

In the majority of eukaryotes, the ribonucleoprotein enzyme telomerase is necessary for the reproduction of chromosome termini. The progenitor cells and cancer cells that are exposed to this chemical are stimulated. In the body, somatic cells usually have little to no activity. An enzyme that adds brief sequence repeats to chromosome ends by replicating a template sequence found in the RNA component of the enzyme’s catalytic component, which is required for the lengthening of telomeres. 

BioCapTM TERT CI (D712A) 3′-3xFLAG mRNA

https://www.pharna.com/product/1600701/

Protein

Telomerase reverse transcriptase

Gene

TERT

Status

UniProtKB reviewed (Swiss-Prot)

Organism

Homo sapiens (Human)

Amino acids

1132

Protein existence

Evidence at protein level

In the majority of eukaryotes, the ribonucleoprotein enzyme telomerase is necessary for the reproduction of chromosome termini. The progenitor cells and cancer cells that are exposed to this chemical are stimulated. An enzyme that adds brief sequence repeats to chromosome ends by replicating a template sequence found in the RNA component of the enzyme’s catalytic component, which is required for the lengthening of telomeres. Chaperones, polypeptide modifiers, and proteins linked with the telomerase complex are a few of the components that control telomerase activity. 

BioCapTM TERT CI (D712A) 5′-3xFLAG 3′-NLS mRNA

https://www.pharna.com/product/1600801/

Protein

Telomerase reverse transcriptase

Gene

TERT

Status

UniProtKB reviewed (Swiss-Prot)

Organism

Homo sapiens (Human)

Amino acids

1132

Protein existence

Evidence at protein level

In most eukaryotes, the ribonucleoprotein enzyme telomerase is necessary for the reproduction of chromosome ends. Progenitor cells and cancer cells exposed to this chemical are stimulated. Telomere elongation occurs when an enzyme replicates the template sequence contained in the RNA component of the catalytic component of the enzyme. Chaperones, polypeptide modifiers, and proteins associated with the telomerase complex are some of the components that control telomerase activity.

BioCapTM Tert mRNA

https://www.pharna.com/product/1600901/

Protein

Telomerase reverse transcriptase

Gene

TERT

Status

UniProtKB reviewed (Swiss-Prot)

Organism

Homo sapiens (Human)

Amino acids

1132

Protein existence

Evidence at protein level

Telomerase is a ribonucleoprotein enzyme indispensable for the replication of chromosome ends in most eukaryotes. This chemical stimulates cancer cells and progenitor cells. A telomere lengthening enzyme replicates the template sequence contained in the catalytic component of the enzyme’s RNA. Chaperones, polypeptide modifiers, and proteins associated with the telomerase complex control telomerase activity.

BioCapTM Terc RNA

https://www.pharna.com/product/1601001/

GENE NAME (BOLD) / SYNONYMS:

Terc

SPECIES:

Mouse

A telomerase holoenzyme gene template is a piece of RNA that carries information about its activity.