INNATE IMMUNITY

The most critical component of the immune system, innate immunity, protects the host from microbial infections. Therefore, it helps to attract immune cells to sites of infection, eliminate microbes, and display antigens to activate adaptive immunity. Bioactive molecules released as part of these key functions of the innate immune system include nuclear factor kappa light chain enhancer of activated B cells (NFkB), protein kinase C (PKC), protein kinase R (PKR), and Toll-like receptors. (TLRs).

BioCapTM MYD88 mRNA

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Protein

Myeloid differentiation primary response protein MyD88

Gene

MYD88

Status

UniProtKB reviewed (Swiss-Prot)

Organism

Homo sapiens (human)

Amino acids

296

Protein existence

Evidence at protein level

A cytosolic adaptor protein encoded by this gene is essential for both the innate and adaptive immune response. The interleukin-1 and Toll-like receptor signaling pathways depend on this protein as a signal generator. An N-terminal death domain and a C-terminal Toll-interleukin 1 receptor region make up the encoded protein. Pyogenic bacterial illnesses are more common in people with this gene defect. Multiple transcript variants arise from alternative splicing.

BioCapTM NFKB1 mRNA

https://www.pharna.com/product/1800201/

Protein

Nuclear factor NF-kappa-B p105 subunit

Gene

NFKB1

Status

UniProtKB reviewed (Swiss-Prot)

Organism

Homo sapiens (human)

Amino acids

968

Protein existence

Evidence at protein level

NFKB1 (nuclear factor kappa B subunit 1) is a protein-coding gene. Immunodeficiency, Common Variable, 12, With Autoimmunity, and Common Variable Immunodeficiency are diseases linked to NFKB1. The TNFR1 pathway and the MyD88-dependent endosome-initiated cascade are two associated pathways. DNA-binding transcription factor activity and sequence-specific DNA binding are two Gene Ontology (GO) categories associated with this gene.

BioCapTM NFKB2 mRNA

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Protein

Nuclear factor NF-kappa-B p100 subunit

Gene

NFKB2

Status

UniProtKB reviewed (Swiss-Prot)

Organism

Homo sapiens (human)

Amino acids

900

Protein existence

Evidence at protein level

A protein-coding gene called NFKB2 codes for nuclear factor kappa B subunit 2. Immunodeficiency 10 and Common Variable Immunodeficiency are diseases connected to NFKB2. This pathway involves endosome and cytosolic sensors of pathogen-associated DNA that are dependent on MyD88. DNA-binding transcription factor activity and transcription coactivator activity are two Gene Ontology (GO) categories connected to this gene. 

BioCapTM PRKCA mRNA

https://www.pharna.com/product/1800401/

Protein

Protein kinase C Alpha type

Gene

PRKCA

Status

UniProtKB reviewed (Swiss-Prot)

Organism

Homo sapiens (human)

Amino acids

672

Protein existence

Evidence at protein level

Protein Kinase C Alpha (PRKCA) is a gene that codes for proteins. The diseases Chordoid Glioma and Cryptosporidiosis are connected to PRKCA. Calmodulin-induced events and prolactin signaling are two of its related mechanisms. Transferase activity, transferring phosphorus-containing groups, and protein tyrosine kinase activity are all annotated in the transcript ontology (GO) for this transcript.

BioCapTM PRKCB mRNA

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Protein

Protein kinase C beta type

Gene

PRKCB

Status

UniProtKB reviewed (Swiss-Prot)

Organism

Homo sapiens (human)

Amino acids

671

Protein existence

Evidence at protein level

Protein Kinase C Beta (PRKCB) is a gene that codes for proteins. Diabetic macular edema and macular retinal edema are diseases connected to PRKCB. Prolactin Signaling and Regulation of Activated PAK-2p34 by Proteasome Mediated Degradation are two of its associated pathways. Transferase activity, transferring phosphorus-containing groups, and protein tyrosine kinase activity are all annotated in the transcript ontology (GO) for this transcript. PRKCA is a significant paralog of this gene.

BioCapTM EIF2AK2 (PKR) mRNA

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Protein

Interferon-induced double-stranded RNA-activated protein kinase

Gene

EIF2AK2

Status

UniProtKB reviewed (Swiss-Prot)

Organism

Homo sapiens (human)

Amino acids

551

Protein existence

Evidence at protein level

This gene produces a serine/threonine protein kinase that binds to dsRNA and is triggered by autophosphorylation. The translation initiation factor EIF2S1 can be phosphorylated by the activated version of the encoded protein, which prevents protein synthesis. Heparin and manganese ions both stimulate this protein’s activity. The encoded protein is crucial to the innate immune system’s defense against various DNA and RNA pathogens.

BioCapTM TLR1 mRNA

https://www.pharna.com/product/1800701/

Protein

Toll-like receptor 1

Gene

TLR1

Status

UniProtKB reviewed (Swiss-Prot)

Organism

Homo sapiens (human)

Amino acids

786

Protein existence

Evidence at protein level

Toll Like Receptor 1 (TLR1) is a gene that codes for proteins. Rheumatoid arthritis and Leprosy 5 are two conditions linked to TLR1. Its related pathways include MyD88-dependent cascades as well as immune system disorders. Protein heterodimerization activity and transmembrane signaling receptor activity are two GO classifications for this gene.

BioCapTM TLR2 mRNA

https://www.pharna.com/product/1800801/

Protein

Toll-like receptor 2

Gene

TLR2

Status

UniProtKB reviewed (Swiss-Prot)

Organism

Homo sapiens (human)

Amino acids

784

Protein existence

Evidence at protein level

Toll Like Receptor 2 (TLR2) is a gene that codes for proteins. TLR2 is linked to leprosy 3 and colorectal cancer among other illnesses. An endosome-dependent cascade and immune system disorders are related. Protein heterodimerization activity and transmembrane signaling receptor activity are two GO classifications for this gene.

BioCapTM TLR3 mRNA

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Protein

Toll-like receptor 3

Gene

TLR3

Status

UniProtKB reviewed (Swiss-Prot)

Organism

Homo sapiens (human)

Amino acids

904

Protein existence

Evidence at protein level

Toll Like Receptor 3 (TLR3) is a gene that codes for proteins. TLR3 is linked to illnesses like Human Immunodeficiency Virus Type 1 and Immunodeficiency 83 Viral Infections. Two related pathways are MyD88-dependent cascades started on endosomes and Toll-Like receptor Signaling Pathways. This gene’s Gene Ontology (GO) annotations mention transmembrane signaling receptors and identical protein binding.

BioCapTM TLR4 mRNA

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Protein

Toll-like receptor 4

Gene

TLR4

Status

UniProtKB reviewed (Swiss-Prot)

Organism

Homo sapiens (human)

Amino acids

839

Protein existence

Evidence at protein level

Toll Like Receptor 4 (TLR4) is a gene that codes for proteins. Macular Degeneration, Age-Related 10, and Pertussis are diseases linked to TLR4. There are two related pathways to this concept: endosome-dependent cascades and immune system disorders. Signaling receptor activity and lipopolysaccharide binding are two GO classifications for this gene.

BioCapTM TLR5 mRNA

https://www.pharna.com/product/1801101/

Protein

Toll-like receptor 5

Gene

TLR5

Status

UniProtKB reviewed (Swiss-Prot)

Organism

Homo sapiens (human)

Amino acids

858

Protein existence

Evidence at protein level

Toll Like Receptor 5 (TLR5) is a gene that codes for proteins. Legionnaires’ disease and melioidosis are diseases connected to TLR5. Among its related pathways are MyD88 dependent cascades and immune system disorders. Interleukin-1 receptor binding and transmembrane signaling receptor activity are two Gene Ontology (GO) categories associated with this gene.

BioCapTM TLR6 mRNA

https://www.pharna.com/product/1801201/

Protein

Toll-like receptor 6

Gene

TLR6

Status

UniProtKB reviewed (Swiss-Prot)

Organism

Homo sapiens (human)

Amino acids

796

Protein existence

Evidence at protein level

Toll Like Receptor 6 (TLR6) is a gene that codes for proteins. Leprosy 1 and Multisystem Inflammatory Syndrome in Children are two conditions linked to TLR6. The MyD88-dependent cascade that starts on endosomes and immune system disorders are two of the pathways involved. Protein heterodimerization activity and transmembrane signaling receptor activity are two GO classifications for this gene.

BioCapTM TLR7 mRNA

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Protein

Toll-like receptor 7

Gene

TLR7

Status

UniProtKB reviewed (Swiss-Prot)

Organism

Homo sapiens (human)

Amino acids

1049

Protein existence

Evidence at protein level

Toll Like Receptor 7 (TLR7) is a gene that codes for proteins. Immunodeficiency 74, Covid-19-Related, X-Linked, and Systemic Lupus Erythematosus 17 are illnesses connected to TLR7. SARS-CoV-2 infection and MyD88-dependent cascade initiated on endosomes are related. This gene’s Gene Ontology (GO) annotations include double-stranded RNA binding and transmembrane signaling receptor function.

BioCapTM TLR8 mRNA

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Protein

Toll-like receptor 8

Gene

TLR8

Status

UniProtKB reviewed (Swiss-Prot)

Organism

Homo sapiens (human)

Amino acids

1041

Protein existence

Evidence at protein level

Toll Like Receptor 8 (TLR8) is a gene that codes for proteins. Immunodeficiency 98 With Autoinflammation, X-Linked, and Anemia, Autoimmune Hemolytic conditions are linked to TLR8. Its associated pathways include SARS-CoV-2 infection and Toll-Like Receptor Signaling Pathways. RNA binding and antiquated drug binding are two Gene Ontology (GO) categories associated with this gene.

BioCapTM TLR9 mRNA

https://www.pharna.com/product/1801501/

Protein

Toll-like receptor 9

Gene

TLR9

Status

UniProtKB reviewed (Swiss-Prot)

Organism

Homo sapiens (human)

Amino acids

1032

Protein existence

Evidence at protein level

Toll Like Receptor 9 (TLR9) is a gene that codes for proteins. TLR9 is linked to cervicitis and esophageal atresia in disease. Its related pathways include the insulin receptor signaling cascade and the MyD88-dependent cascade starting at the endosome. Transmembrane signaling receptor activity and siRNA binding are two Gene Ontology (GO) categories associated with this gene.

BioCapTM TLR10 mRNA

https://www.pharna.com/product/1801601/

Protein

Toll-like receptor 10

Gene

TLR10

Status

UniProtKB reviewed (Swiss-Prot)

Organism

Homo sapiens (human)

Amino acids

811

Protein existence

Evidence at protein level

Toll Like Receptor 10 (TLR10) is a gene that codes for proteins. Melioidosis and tonsillitis are linked to TLR10. In addition to MyD88-dependent cascades, Toll-Like receptor signaling pathways are related pathways. Transmembrane signaling receptor activity is one of this gene’s Gene Ontology (GO) categories.