PhaRNA WORLD’S LARGEST CATALOG OF PREMADE SYNTHETIC MRNA ENCODING CYTOKINES.

Cytokines are small proteins that play critical role in controlling the growth and activity of others immune system and blood cells. When released, they signal to immune system to respond to internal and external challenges. Cytokines affect the growth of all blood cells and other cells that help the body’s immune and inflammatory responses. PhaRNA, LLC (https://www.pharna.com/) offers premade synthetic mRNAs encoding for dozens of cytokines including Chemokine, Interleukin, TNF, TGF, and Interferon families (https://www.pharna.com/cytokines-mrna/).

Each synthetic cytokine mRNA is produced from an error-free pDNA template (no PCR) of the gene of interest, 5′ and 3′ stabilizing untranslated regions (UTRs), capped with enzymatically introduced translation-enhancing Cap 1 structure (BioCapTM), terminated with an extra-long 157 residue constant poly-A tail and synthesized as modified mRNA with 100% uridine (UTP) replacement by chemically modified UTP analogs – N1-methyl pseudo-UTP. All these features provide PhaRNA generated synthetic mRNAs with improved pharmacological parameters such as reduced toxicity and increased stability and translational efficiency.

Since 2016, PhaRNA has been a trusted name in the synthetic RNA space, providing best-in-class, innovative synthetic RNA products to the scientific community and pharmaceutical and cosmeceutical organizations. PhaRNA established world’s largest catalog of premade synthetic mRNA cytokines (https://www.pharna.com/cytokines-mrna/) and provides a broad range of one-stop shop services including customized Research Grade and GMP Grade synthetic mRNA production, making it an ideal solution for preclinical and clinical applications. 

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