• Call for Collaboration / Partnership

Tel: +1 (877) 974-2762
mRNA Products | Next Generation RNA Technologies
  • Home
  • Products
  • Orders
    • My Account
  • Services
  • About
    • Testimonials
  • Contact
  • Menu
  • 0Shopping Cart
Awaiting product image
×

***Note: The minimum order quantity for international customers (outside of the United States) is 1,000ug.***


Categories


CELL LINEAGE SPECIFIC FACTORS GROWTH FACTORS GROWTH FACTOR RECEPTORS CYTOKINES CYTOKINE RECEPTORS REPORTER PROTEINS GENOME INTEGRITY APOPTOSIS INNATE IMMUNITY DEVELOPMENTAL BIOLOGY MISCELLANEOUS
Modified nucleotides: 100% 5-methoxyuridine

Cap type: BioCapTM Cap1

Country of origin: USA

For research use only. Not for use in humans. Not for resale without express written permission of phaRNA. The purchase of any phaRNA product does not grant or imply any license under any patent or patent pending. phaRNA does not warrant that any use or sale of products provided by phaRNA will not infringe the claims of any patents or patents pending in the United States or elsewhere covering the use of the product alone or in combination with other products or in the operation of any process. The purchaser has sole responsibility for all and any use of phaRNA products.



Customer Registration

  • Register
  • Log in
  • Entries feed
  • Comments feed
  • WordPress.org

BioCapTM NANOG mRNA

Catalog Number: 1000601
SKUPriceBuy
1000601-100ug$412.50
1000601-250ug$792.00
1000601-500ug$1,446.50
1000601-1mg$2,689.50
Ships in ~5 business days

Description

GENE NAME (BOLD) / SYNONYMS:

NANOG

SPECIES:

Human

ENCODED PROTEIN NAME:

Homeobox protein NANOG

Function:

Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (PubMed:25825768). Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation. (Source: UniProt http://www.uniprot.org/uniprot/q9h9s0)

Sequence (305 aa):

MSVDPACPQS LPCFEASDCK ESSPMPVICG PEENYPSLQM SSAEMPHTET VSPLPSSMDL LIQDSPDSST SPKGKQPTSA EKSVAKKEDK VPVKKQKTRT VFSSTQLCVL NDRFQRQKYL SLQQMQELSN ILNLSYKQVK TWFQNQRMKS KRWQKNNWPK NSNGVTQKAS APTYPSLYSS YHQGCLVNPT GNLPMWSNQT WNNSTWSNQT QNIQSWSNHS WNTQTWCTQS WNNQAWNSPF YNCGEESLQS CMQFQPNSPA SDLEAALEAA GEGLNVIQQT TRYFSTPQTM DLFLNYSMNM QPEDV

 

Gene Coding Sequence:

For the DNA coding sequence that is used as the template to synthesize the NANOG mRNA mimetic, please contact us at customerservice@pharna.com.

For potential mRNA mimetics encoding splice variants or isoforms of your interest, please contact us at customerservice@pharna.com and it is our promise to fulfill your needs.


Related products

  • BioCapTM MYC mRNA

    $412.50 – $2,689.50
    Select options
  • BioCapTM SOX2 mRNA

    $412.50 – $2,689.50
    Select options
  • BioCapTM POU5F1 mRNA

    $412.50 – $2,689.50
    Select options
  • BioCapTM KLF4 mRNA

    $412.50 – $2,689.50
    Select options
© Copyright 2022 - PhaRNA
  • Home
  • Products
  • Orders
  • Services
  • About
  • Contact
BioCapTM... BioCapTM...
MENU
  • Home
  • Products
  • Orders
    • My Account
  • Services
  • About
    • Testimonials
  • Contact
Scroll to top