Tel: +1 (877) 974-2762
mRNA Products | Next Generation RNA Technologies
  • Home
  • Products
  • Orders
  • Services
    • Applications
  • About
    • Testimonials
  • Contact
  • Search
  • Menu
  • 0Shopping Cart
Awaiting product image

Categories


CELL LINEAGE SPECIFIC FACTORS GROWTH FACTORS GROWTH FACTOR RECEPTORS CYTOKINES CYTOKINE RECEPTORS REPORTER PROTEINS GENOME INTEGRITY APOPTOSIS INNATE IMMUNITY DEVELOPMENTAL BIOLOGY MISCELLANEOUS
Modified nucleotides: 100% 5-methoxyuridine

Cap type: BioCapTM Cap1

Country of origin: USA

For research use only. Not for use in humans. Not for resale without express written permission of phaRNA. The purchase of any phaRNA product does not grant or imply any license under any patent or patent pending. phaRNA does not warrant that any use or sale of products provided by phaRNA will not infringe the claims of any patents or patents pending in the United States or elsewhere covering the use of the product alone or in combination with other products or in the operation of any process. The purchaser has sole responsibility for all and any use of phaRNA products.



BioCapTM ASCL1 mRNA

Catalog Number: 1003501
SKUPriceBuy
1003501-500ug$1,550.00
1003501-1mg$2,025.00
Ships in ~5 business days

Description

GENE NAME (BOLD) / SYNONYMS:

ASCL1 / ASH1 BHLHA46 HASH1

SPECIES:

Human

ENCODED PROTEIN NAME:

Achaete-scute homolog 1

Function:

Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. (Source: UniProt http://www.uniprot.org/uniprot/p50553)

Sequence (236 aa):

MESSAKMESG GAGQQPQPQP QQPFLPPAAC FFATAAAAAA AAAAAAAQSA QQQQQQQQQQ QQAPQLRPAA DGQPSGGGHK SAPKQVKRQR SSSPELMRCK RRLNFSGFGY SLPQQQPAAV ARRNERERNR VKLVNLGFAT LREHVPNGAA NKKMSKVETL RSAVEYIRAL QQLLDEHDAV SAAFQAGVLS PTISPNYSND LNSMAGSPVS SYSSDEGSYD PLSPEEQELL DFTNWF

Gene Coding Sequence:

For the DNA coding sequence that is used as the template to synthesize the ASCL1 mRNA mimetic, please contact us at customerservice@pharna.com.

For potential mRNA mimetics encoding splice variants or isoforms of your interest, please contact us at customerservice@pharna.com and it is our promise to fulfill your needs.


Related products

  • BioCapTM NEUROD2 mRNA

    $1,550.00 – $2,025.00
    Select options
  • BioCapTM ZIC1 mRNA

    $1,550.00 – $2,025.00
    Select options
  • BioCapTM POU3F2 mRNA

    $1,550.00 – $2,025.00
    Select options
  • BioCapTM NEUROG2 mRNA

    $1,550.00 – $2,025.00
    Select options
© Copyright 2019 - PhaRNA
  • Home
  • Products
  • Orders
  • Services
  • About
  • Contact
BioCapTM... BioCapTM...
MENU
  • Home
  • Products
  • Orders
  • Services
    • Applications
  • About
    • Testimonials
  • Contact
Scroll to top