• Next Generation of mRNA Technologies

Tel: +1 (877) 974-2762
mRNA Products | Next Generation RNA Technologies
  • HOME
  • mRNA PRODUCTS
    • REPORTER PROTEINS
    • GROWTH FACTORS
    • CELL LINEAGE SPECIFIC
    • CYTOKINES
    • CYTOKINE RECEPTORS
    • GENOME INTEGRITY
    • APOPTOSIS
    • INNATE IMMUNITY
    • DEVELOPMENTAL BIOLOGY
    • MISCELLANEOUS
    • GROWTH FACTOR RECEPTORS
  • ORDERS
    • My Account
  • SERVICES
  • ABOUT
    • Blog
    • Testimonials
  • CONTACT
  • Menu
  • 0Shopping Cart
Awaiting product image
×
***The minimum order quantity for international customers (outside of the United States) is 1,000 μg***

Categories


REPORTER PROTEINS CELL LINEAGE SPECIFIC FACTORS GROWTH FACTORS GROWTH FACTOR RECEPTORS CYTOKINES CYTOKINE RECEPTORS GENOME INTEGRITY APOPTOSIS INNATE IMMUNITY DEVELOPMENTAL BIOLOGY MISCELLANEOUS

Customer Registration

  • Register
  • Log in
  • Entries feed
  • Comments feed
  • WordPress.org

BioCapTM ASCL1 mRNA

Catalog Number: 1003501
SKUPriceBuy
1003501-500ug$1,705.00
1003501-1mg$2,227.50
Ships in ~5 business days

Description

GENE NAME (BOLD) / SYNONYMS:

ASCL1 / ASH1 BHLHA46 HASH1

SPECIES:

Human

ENCODED PROTEIN NAME:

Achaete-scute homolog 1

Function:

Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. (Source: UniProt http://www.uniprot.org/uniprot/p50553)

Sequence (236 aa):

MESSAKMESG GAGQQPQPQP QQPFLPPAAC FFATAAAAAA AAAAAAAQSA QQQQQQQQQQ QQAPQLRPAA DGQPSGGGHK SAPKQVKRQR SSSPELMRCK RRLNFSGFGY SLPQQQPAAV ARRNERERNR VKLVNLGFAT LREHVPNGAA NKKMSKVETL RSAVEYIRAL QQLLDEHDAV SAAFQAGVLS PTISPNYSND LNSMAGSPVS SYSSDEGSYD PLSPEEQELL DFTNWF

Gene Coding Sequence:

For the DNA coding sequence that is used as the template to synthesize the ASCL1 mRNA mimetic, please contact us at customerservice@pharna.com.

For potential mRNA mimetics encoding splice variants or isoforms of your interest, please contact us at customerservice@pharna.com and it is our promise to fulfill your needs.


Related products

  • BioCapTM MNX1 mRNA

    $1,705.00 – $2,227.50
    Select options
  • BioCapTM ISL1 mRNA

    $1,705.00 – $2,227.50
    Select options
  • BioCapTM NEUROD1 mRNA

    $1,705.00 – $2,227.50
    Select options
  • BioCapTM FOXA2 mRNA

    $1,705.00 – $2,227.50
    Select options
© Copyright 2022 - PhaRNA
  • Linkedin
  • Gplus
  • HOME
  • mRNA PRODUCTS
  • ORDERS
  • SERVICES
  • ABOUT
  • CONTACT
BioCapTM... BioCapTM...
MENU
  • HOME
  • mRNA PRODUCTS
    • REPORTER PROTEINS
    • GROWTH FACTORS
    • CELL LINEAGE SPECIFIC
    • CYTOKINES
    • CYTOKINE RECEPTORS
    • GENOME INTEGRITY
    • APOPTOSIS
    • INNATE IMMUNITY
    • DEVELOPMENTAL BIOLOGY
    • MISCELLANEOUS
    • GROWTH FACTOR RECEPTORS
  • ORDERS
    • My Account
  • SERVICES
  • ABOUT
    • Blog
    • Testimonials
  • CONTACT
Scroll to top