Tel: +1 (877) 974-2762
mRNA Products | Next Generation RNA Technologies
  • Home
  • Products
  • Orders
  • Services
    • Applications
  • About
    • Testimonials
  • Contact
  • Search
  • Menu
  • 0Shopping Cart
Awaiting product image

Categories


CELL LINEAGE SPECIFIC FACTORS GROWTH FACTORS GROWTH FACTOR RECEPTORS CYTOKINES CYTOKINE RECEPTORS REPORTER PROTEINS GENOME INTEGRITY APOPTOSIS INNATE IMMUNITY DEVELOPMENTAL BIOLOGY MISCELLANEOUS
Modified nucleotides: 100% 5-methoxyuridine

Cap type: BioCapTM Cap1

Country of origin: USA

For research use only. Not for use in humans. Not for resale without express written permission of phaRNA. The purchase of any phaRNA product does not grant or imply any license under any patent or patent pending. phaRNA does not warrant that any use or sale of products provided by phaRNA will not infringe the claims of any patents or patents pending in the United States or elsewhere covering the use of the product alone or in combination with other products or in the operation of any process. The purchaser has sole responsibility for all and any use of phaRNA products.



BioCapTM CXCR3 mRNA

Catalog Number: 1401501
SKUPriceBuy
1401501-500ug$1,550.00
1401501-1mg$2,025.00
Ships in ~5 business days

Description

GENE NAME (BOLD) / SYNONYMS:

CXCR3 / GPR9

SPECIES:

Human

ENCODED PROTEIN NAME:

C-X-C chemokine receptor type 3

Function:

Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response. Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. Isoform 3: Mediates the activity of CXCL11. (Source: UniProt http://www.uniprot.org/uniprot/p49682)

Sequence (368 aa):

MVLEVSDHQV LNDAEVAALL ENFSSSYDYG ENESDSCCTS PPCPQDFSLN FDRAFLPALY SLLFLLGLLG NGAVAAVLLS RRTALSSTDT FLLHLAVADT LLVLTLPLWA VDAAVQWVFG SGLCKVAGAL FNINFYAGAL LLACISFDRY LNIVHATQLY RRGPPARVTL TCLAVWGLCL LFALPDFIFL SAHHDERLNA THCQYNFPQV GRTALRVLQL VAGFLLPLLV MAYCYAHILA VLLVSRGQRR LRAMRLVVVV VVAFALCWTP YHLVVLVDIL MDLGALARNC GRESRVDVAK SVTSGLGYMH CCLNPLLYAF VGVKFRERMW MLLLRLGCPN QRGLQRQPSS SRRDSSWSET SEASYSGL

Gene Coding Sequence:

For the DNA coding sequence that is used as the template to synthesize the CXCR3 mRNA mimetic, please contact us at customerservice@pharna.com.

For potential mRNA mimetics encoding splice variants or isoforms of your interest, please contact us at customerservice@pharna.com and it is our promise to fulfill your needs.


Related products

  • BioCapTM CXCR4 mRNA

    $1,550.00 – $2,025.00
    Select options
  • BioCapTM CXCR6 mRNA

    $1,550.00 – $2,025.00
    Select options
  • BioCapTM CCR3 mRNA

    $1,550.00 – $2,025.00
    Select options
  • BioCapTM CCR9 mRNA

    $1,550.00 – $2,025.00
    Select options
© Copyright 2019 - PhaRNA
  • Home
  • Products
  • Orders
  • Services
  • About
  • Contact
BioCapTM... BioCapTM...
MENU
  • Home
  • Products
  • Orders
  • Services
    • Applications
  • About
    • Testimonials
  • Contact
Scroll to top