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Modified nucleotides: 100% 5-methoxyuridine

Cap type: BioCapTM Cap1

Country of origin: USA

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BioCapTM IFNAR2 mRNA

Catalog Number: 1406401
SKUPriceBuy
1406401-500ug$1,705.00
1406401-1mg$2,227.50
Ships in ~5 business days

Description

GENE NAME (BOLD) / SYNONYMS:

IFNAR2 / IFNABR IFNARB

SPECIES:

Human

ENCODED PROTEIN NAME:

Interferon alpha/beta receptor 2

Function:

Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950). (Source: UniProt http://www.uniprot.org/uniprot/p48551)

Sequence (515 aa):

MLLSQNAFIF RSLNLVLMVY ISLVFGISYD SPDYTDESCT FKISLRNFRS ILSWELKNHS IVPTHYTLLY TIMSKPEDLK VVKNCANTTR SFCDLTDEWR STHEAYVTVL EGFSGNTTLF SCSHNFWLAI DMSFEPPEFE IVGFTNHINV MVKFPSIVEE ELQFDLSLVI EEQSEGIVKK HKPEIKGNMS GNFTYIIDKL IPNTNYCVSV YLEHSDEQAV IKSPLKCTLL PPGQESESAE SAKIGGIITV FLIALVLTST IVTLKWIGYI CLRNSLPKVL NFHNFLAWPF PNLPPLEAMD MVEVIYINRK KKVWDYNYDD ESDSDTEAAP RTSGGGYTMH GLTVRPLGQA SATSTESQLI DPESEEEPDL PEVDVELPTM PKDSPQQLEL LSGPCERRKS PLQDPFPEED YSSTEGSGGR ITFNVDLNSV FLRVLDDEDS DDLEAPLMLS SHLEEMVDPE DPDNVQSNHL LASGEGTQPT FPSPSSEGLW SEDAPSDQSD TSESDVDLGD GYIMR

Gene Coding Sequence:

For the DNA coding sequence that is used as the template to synthesize the IFNAR2 mRNA mimetic, please contact us at customerservice@pharna.com.

For potential mRNA mimetics encoding splice variants or isoforms of your interest, please contact us at customerservice@pharna.com and it is our promise to fulfill your needs.


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