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***The minimum order quantity for international customers (outside of the United States) is 1,000 μg***

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REPORTER PROTEINS CELL LINEAGE SPECIFIC FACTORS GROWTH FACTORS GROWTH FACTOR RECEPTORS CYTOKINES CYTOKINE RECEPTORS GENOME INTEGRITY APOPTOSIS INNATE IMMUNITY DEVELOPMENTAL BIOLOGY MISCELLANEOUS

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BioCapTM BAX mRNA

Catalog Number: 1700201
SKUPriceBuy
1700201-500ug$1,705.00
1700201-1mg$2,227.50
Ships in ~5 business days

Description

GENE NAME (BOLD) / SYNONYMS:

BAX / BCL2L4

SPECIES:

Human

ENCODED PROTEIN NAME:

Apoptosis regulator BAX

Function:

Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. (Source: UniProt http://www.uniprot.org/uniprot/q07812)

Sequence (192 aa):

MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV PQDASTKKLS ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF SDGNFNWGRV VALFYFASKL VLKALCTKVP ELIRTIMGWT LDFLRERLLG WIQDQGGWDG LLSYFGTPTW QTVTIFVAGV LTASLTIWKK MG

Gene Coding Sequence:

For the DNA coding sequence that is used as the template to synthesize the BAX mRNA mimetic, please contact us at customerservice@pharna.com.

For potential mRNA mimetics encoding splice variants or isoforms of your interest, please contact us at customerservice@pharna.com and it is our promise to fulfill your needs.


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