BioCapTM BAX mRNA
Catalog Number: 1700201| SKU | Price | Buy |
|---|---|---|
| 1700201-500ug | $1,550.00 | |
| 1700201-1mg | $2,025.00 |
Ships in ~5 business days
Description
GENE NAME (BOLD) / SYNONYMS:
BAX / BCL2L4
SPECIES:
Human
ENCODED PROTEIN NAME:
Apoptosis regulator BAX
Function:
Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. (Source: UniProt http://www.uniprot.org/uniprot/q07812)
Sequence (192 aa):
BAX / BCL2L4
SPECIES:
Human
ENCODED PROTEIN NAME:
Apoptosis regulator BAX
Function:
Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. (Source: UniProt http://www.uniprot.org/uniprot/q07812)
Sequence (192 aa):
MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV PQDASTKKLS ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF SDGNFNWGRV VALFYFASKL VLKALCTKVP ELIRTIMGWT LDFLRERLLG WIQDQGGWDG LLSYFGTPTW QTVTIFVAGV LTASLTIWKK MG
Gene Coding Sequence:
For the DNA coding sequence that is used as the template to synthesize the BAX mRNA mimetic, please contact us at customerservice@pharna.com.
For potential mRNA mimetics encoding splice variants or isoforms of your interest, please contact us at customerservice@pharna.com and it is our promise to fulfill your needs.
For the DNA coding sequence that is used as the template to synthesize the BAX mRNA mimetic, please contact us at customerservice@pharna.com.
For potential mRNA mimetics encoding splice variants or isoforms of your interest, please contact us at customerservice@pharna.com and it is our promise to fulfill your needs.