BioCapTM SERPINA1 Z Type mutant mRNA
Catalog Number: 2000301| SKU | Price | Buy |
|---|---|---|
| 2000301-500ug | $1,705.00 | |
| 2000301-1mg | $2,227.50 |
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Description
GENE NAME (BOLD) / SYNONYMS:
SERPINA1 / AAT PI
SPECIES:
Human
ENCODED PROTEIN NAME:
Alpha-1-antitrypsin Z Type mutant
Function:
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE). (Source: UniProt http://www.uniprot.org/uniprot/p01009)
Sequence (418 aa):
SERPINA1 / AAT PI
SPECIES:
Human
ENCODED PROTEIN NAME:
Alpha-1-antitrypsin Z Type mutant
Function:
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE). (Source: UniProt http://www.uniprot.org/uniprot/p01009)
Sequence (418 aa):
MPSSVSWGIL LLAGLCCLVP VSLAEDPQGD AAQKTDTSHH DQDHPTFNKI TPNLAEFAFS LYRQLAHQSN STNIFFSPVS IATAFAMLSL GTKADTHDEI LEGLNFNLTE IPEAQIHEGF QELLRTLNQP DSQLQLTTGN GLFLSEGLKL VDKFLEDVKK LYHSEAFTVN FGDTEEAKKQ INDYVEKGTQ GKIVDLVKEL DRDTVFALVN YIFFKGKWER PFEVKDTEEE DFHVDQVTTV KVPMMKRLGM FNIQHCKKLS SWVLLMKYLG NATAIFFLPD EGKLQHLENE LTHDIITKFL ENEDRRSASL HLPKLSITGT YDLKSVLGQL GITKVFSNGA DLSGVTEEAP LKLSKAVHKA VLTIDKKGTE AAGAMFLEAI PMSIPPEVKF NKPFVFLMIE QNTKSPLFMG KVVNPTQK
Variant: Z Type mutant
This is the Z Type mutant of SERPINA1.
Gene Coding Sequence:
For the DNA coding sequence that is used as the template to synthesize the SERPINA1 mRNA mimetic, please contact us at customerservice@pharna.com.
For potential mRNA mimetics encoding splice variants or isoforms of your interest, please contact us at customerservice@pharna.com and it is our promise to fulfill your needs.
This is the Z Type mutant of SERPINA1.
Gene Coding Sequence:
For the DNA coding sequence that is used as the template to synthesize the SERPINA1 mRNA mimetic, please contact us at customerservice@pharna.com.
For potential mRNA mimetics encoding splice variants or isoforms of your interest, please contact us at customerservice@pharna.com and it is our promise to fulfill your needs.