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CELL LINEAGE SPECIFIC FACTORS GROWTH FACTORS GROWTH FACTOR RECEPTORS CYTOKINES CYTOKINE RECEPTORS REPORTER PROTEINS GENOME INTEGRITY APOPTOSIS INNATE IMMUNITY DEVELOPMENTAL BIOLOGY MISCELLANEOUS
Modified nucleotides: 100% 5-methoxyuridine

Cap type: BioCapTM Cap1

Country of origin: USA

For research use only. Not for use in humans. Not for resale without express written permission of phaRNA. The purchase of any phaRNA product does not grant or imply any license under any patent or patent pending. phaRNA does not warrant that any use or sale of products provided by phaRNA will not infringe the claims of any patents or patents pending in the United States or elsewhere covering the use of the product alone or in combination with other products or in the operation of any process. The purchaser has sole responsibility for all and any use of phaRNA products.



BioCapTM CXCL12 Isoform alpha mRNA

Catalog Number: 2000501
SKUPriceBuy
2000501-500ug$1,550.00
2000501-1mg$2,025.00
Ships in ~5 business days

Description

GENE NAME (BOLD) / SYNONYMS:

CXCL12 / SDF1 SDF1A SDF1B

SPECIES:

Human

ENCODED PROTEIN NAME:

Stromal cell-derived factor 1 Isoform alpha

Function:

Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (PubMed:29301984). Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (By similarity). (Source: UniProt http://www.uniprot.org/uniprot/p48061)

Sequence (89 aa):

MNAKVVVVLV LVLTALCLSD GKPVSLSYRC PCRFFESHVA RANVKHLKIL NTPNCALQIV ARLKNNNRQV CIDPKLKWIQ EYLEKALNK

Variant: Isoform alpha

Gene Coding Sequence:

For the DNA coding sequence that is used as the template to synthesize the CXCL12 mRNA mimetic, please contact us at customerservice@pharna.com.

For potential mRNA mimetics encoding splice variants or isoforms of your interest, please contact us at customerservice@pharna.com and it is our promise to fulfill your needs.


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