• Next Generation of mRNA Technologies

Tel: +1 (877) 974-2762
mRNA Products | Next Generation RNA Technologies
  • HOME
  • SYNTHETIC MRNA PRODUCTS
  • ORDERS
    • My Account
  • SERVICES
  • ABOUT
    • Blog
    • Testimonials
  • CONTACT
  • Menu
  • 0Shopping Cart
Awaiting product image
×
***The minimum order quantity for international customers (outside of the United States) is 1,000 μg***

Categories


REPORTER PROTEINS CELL LINEAGE SPECIFIC FACTORS GROWTH FACTORS GROWTH FACTOR RECEPTORS CYTOKINES CYTOKINE RECEPTORS GENOME INTEGRITY APOPTOSIS INNATE IMMUNITY DEVELOPMENTAL BIOLOGY MISCELLANEOUS

Customer Registration

  • Register
  • Log in
  • Entries feed
  • Comments feed
  • WordPress.org

BioCapTM CXCL12 Isoform alpha mRNA

Catalog Number: 2000501
SKUPriceBuy
2000501-500ug$1,705.00
2000501-1mg$2,227.50
Ships in ~5 business days

Description

GENE NAME (BOLD) / SYNONYMS:

CXCL12 / SDF1 SDF1A SDF1B

SPECIES:

Human

ENCODED PROTEIN NAME:

Stromal cell-derived factor 1 Isoform alpha

Function:

Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (PubMed:29301984). Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (By similarity). (Source: UniProt http://www.uniprot.org/uniprot/p48061)

Sequence (89 aa):

MNAKVVVVLV LVLTALCLSD GKPVSLSYRC PCRFFESHVA RANVKHLKIL NTPNCALQIV ARLKNNNRQV CIDPKLKWIQ EYLEKALNK

Variant: Isoform alpha

Gene Coding Sequence:

For the DNA coding sequence that is used as the template to synthesize the CXCL12 mRNA mimetic, please contact us at customerservice@pharna.com.

For potential mRNA mimetics encoding splice variants or isoforms of your interest, please contact us at customerservice@pharna.com and it is our promise to fulfill your needs.


Related products

  • BioCapTM ERAS mRNA

    $1,705.00 – $2,227.50
    Select options

    BioCapTM ERAS mRNA

    GTPase ERas

    SKU: 2000101 Category: Miscellaneous
    $1,705.00 – $2,227.50
  • BioCapTM Tbx5 mRNA

    $1,705.00 – $2,227.50
    Select options

    BioCapTM Tbx5 mRNA

    T-box transcription factor TBX5

    SKU: 2001001 Category: Miscellaneous
    $1,705.00 – $2,227.50
  • BioCapTM OLA1 mRNA

    $1,705.00 – $2,227.50
    Select options

    BioCapTM OLA1 mRNA

    Obg-like ATPase 1

    SKU: 2000701 Category: Miscellaneous
    $1,705.00 – $2,227.50
  • BioCapTM SERPINA1 Z Type mutant mRNA

    $1,705.00 – $2,227.50
    Select options

    BioCapTM SERPINA1 Z Type mutant mRNA

    Alpha-1-antitrypsin Z Type mutant

    SKU: 2000301 Category: Miscellaneous
    $1,705.00 – $2,227.50
© Copyright 2023 - PhaRNA
  • Linkedin
  • Gplus
  • HOME
  • SYNTHETIC MRNA PRODUCTS
  • ORDERS
  • SERVICES
  • ABOUT
  • CONTACT
BioCapTM... BioCapTM...
MENU
  • HOME
  • SYNTHETIC MRNA PRODUCTS
  • ORDERS
    • My Account
  • SERVICES
  • ABOUT
    • Blog
    • Testimonials
  • CONTACT
Scroll to top